Development and optimization of tools for the study of human brain anatomical connectivity using high angular resolution diffusion MRI

Project Type: FONDECYT Initiation #11121644
Position: Principal Researcher
Award Year: 2012. Ending Year: 2015.

Descripción

This project sought to develop and optimize tools for the study and analysis of brain connectivity, using Difussion Magnetic Resonance Imaging (dMRI) data.

The studies are based on High Angular Resolution Difussion Imaging (HARDI) images.

These present very high quality, due to the advancement of acquisition technologies, as well as the acquisition itself (long duration, dedicated to research) and the performed post-processing, which seek to provide a solid base for the study of the healthy adult human brain.

The main results of this project contemplate:

  • The analysis of the reproducibility of short association fascicles of the brain, using data clustering tools and cortical parcellations.

  • The optimization of an algorithm for the segmentation of brain fibers, achieving times that allow an interactive segmentation (Principal Researcher: Professor Miguel Figueroa T.).

  • The development of a tool for the optimized visualization and manipulation of brain tracts.

Other interesting results are:

  • Development of a tool for the optimized visualization of tracts for Android devices (iFiber).

  • Creation of an atlas of short brain fascicles.

  • Development of algorithms for the comparison of brain tracts, between subjects and between hemispheres.

Undergraduate Theses related to the project

Student Thesis Defense Date
Ignacio Osorio W. Electronic Civil Engineering Thesis: “Software for the Interactive Visualization and Extraction of Brain Fibers” December 31st, 2015.
Danilo Bonometti B. Electronic Civil Engineering Thesis: “Visualization of Brain Fibers” April 1st, 2015.
Daniel Seguel B. Biomedical Civil Engineering Thesis: “Automatic Algorithm for the Segmentation of Short Association Fibers of the Human Brain” March 17th, 2015.
Claudio Román G. Biomedical Civil Engineering Thesis: “Short Brain Fibers Clustering Calculated from Difussion Magnetic Resonance Imaging Images” January 16th, 2015.
Miguel Guevara O. Biomedical Civil Engineering Thesis: “Algorithm for the Automatic Segmentation of Short Brain Fibers of the Fronto-Parietal Region and the Insular Cortex” January 16th, 2015.
Pablo L. Silva P. Biomedical Civil Engineering Thesis: “Parcellation of the Brain Cortex Based on the Anatomical Connectivity” May 29th, 2014.
Eduardo Venegas A. Electronic Civil Engineering Thesis: “Development of a software for the interactive manipulation of brain fibers” July 18th, 2014.
Nicole A. Labra A. Biomedical Civil Engineering Thesis: “Optimization of Algorithm for the Classification of White Matter Fibers based on the Brain Fascicles Atlas” April 30th, 2013.
Edison Pardo R. Electronic Civil Engineering Thesis: “Study of the Variability of the Connections of Short Association of the Human Brain” April 4th, 2013.
Gabriel E. Varela M. Biomedical Civil Engineering Thesis: “Calculation of Diffusion Tensor Indices from the Westin Algorithm” April 4th, 2013.

Postgraduate Theses related to the project

Student Thesis Defense Date
Claudio Román G. Master of Engineering Sciences w/m in Electrical Engineering.
“Segmentation of brain short brain fibers based on hierarchical Clustering from HARDI database”
November 30th, 2016.
Miguel Guevara O. Master of Engineering Sciences w/m in Electrical Engineering.
“Parcellation of the brain cortex based on fiber atlas calculated from tractography”
January 30th, 2016.
Nicole Labra A. Master of Engineering Sciences w/m in Electrical Engineering, (co-director)
“Quick segmentation of white substance brain fibers”
January 28th, 2015.

Publications

206, 2013

A multicenter tractography study of white matter integrity in bipolar disorder and effects of psychotic features.

S. Sarrazin, C. Poupon, J. Linke, M. Wessa, M. Phillips, M. Delavest, A. Versace, J. Almeida, P. Guevara, D. Duclap, E. Duchesnay, J.-F. Mangin, K. Le Dudal, C. Daban, M. Leboyer, J. Houenou. A multicenter tractography study of white matter integrity in bipolar disorder and effects of psychotic features. International Conference of Bipolar Disorders, Vol. 15, pp. 42-42. Miami, Florida, Junio 2013.

3005, 2013

ISBI Conference at Salt Lake City, USA

  From April 20th to the 26th, 2013, the 21st Annual International Conference of the International Society for Magnetic Resonance in Medicine (ISMRM’14) was held at Salt Lake City, USA.   The Electronic Civil Engineer student Edison Pardo presented the paper “Study of the variability of short association bundles segmented using an automatic method on a HARDI database”.

2604, 2013

Towards probabilistic atlases of the T1/T2 relaxation times from the CONNECT/ARCHI database.

A. Lebois, D. Duclap, B. Schmitt, C. Longo Dos Santos, P. Guevara, H. Zhang, D. Le Bihan, J. Mangin and C. Poupon.Towards probabilistic atlases of the T1/T2 relaxation times from the CONNECT/ARCHI database. In International Society of Magnetic Resonance in Medicine conference, ISMRM 2013, Salt Lake City, USA, 2013. http://www0.cs.ucl.ac.uk/staff/G.Zhang/papers/lebois13ismrm.pdf

2604, 2013

Towards a super-resolution CONNECT/Archi atlas of the white matter connectivity.

D. Duclap, B. Schmitt, A. Lebois, P. Guevara, H. Zhang, C. Longo Dos Santos, D. Le Bihan, J. Mangin and C. Poupon. Towards a super-resolution CONNECT/Archi atlas of the white matter connectivity. In International Society of Magnetic Resonance in Medicine conference, ISMRM 2013, Salt Lake City, USA, 2013. http://www0.cs.ucl.ac.uk/staff/G.Zhang/papers/duclap13ismrm.pdf

2604, 2013

A novel probabilistic connectivity atlas for the human connectome : the CONNECT/ARCHI atlas.

B. Schmitt, D. Duclap, A. Lebois, P. Guevara, H. Zhang, Y. Assaf, F. Poupon, D. Rivière, Y. Cointepas, D. Le Bihan, J. Mangin and C. Poupon. A novel probabilistic connectivity atlas for the human connectome : the CONNECT/ARCHI atlas. In International Society of Magnetic Resonance in Medicine conference, ISMRM 2013, Salt Lake City, USA, 2013. http://www0.cs.ucl.ac.uk/staff/G.Zhang/papers/schmitt13ismrm.pdf

News

2508, 2017

Biomedical Engineering in Special Edition about Health Informatics in El Mercurio newspaper

We highlight a report about Biomedical Civil Engineering of University of Concepción in El Mercurio newspaper, in its special edition about Health Informatics, from August 24th, 2017. Biomedical [...]

2018-11-10T18:32:47-03:00

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