Development and optimization of tools for the study of human brain anatomical connectivity using high angular resolution diffusion MRI

Project Type: FONDECYT Initiation #11121644
Position: Principal Researcher
Award Year: 2012. Ending Year: 2015.

Descripción

This project sought to develop and optimize tools for the study and analysis of brain connectivity, using Difussion Magnetic Resonance Imaging (dMRI) data.

The studies are based on High Angular Resolution Difussion Imaging (HARDI) images.

These present very high quality, due to the advancement of acquisition technologies, as well as the acquisition itself (long duration, dedicated to research) and the performed post-processing, which seek to provide a solid base for the study of the healthy adult human brain.

The main results of this project contemplate:

  • The analysis of the reproducibility of short association fascicles of the brain, using data clustering tools and cortical parcellations.

  • The optimization of an algorithm for the segmentation of brain fibers, achieving times that allow an interactive segmentation (Principal Researcher: Professor Miguel Figueroa T.).

  • The development of a tool for the optimized visualization and manipulation of brain tracts.

Other interesting results are:

  • Development of a tool for the optimized visualization of tracts for Android devices (iFiber).

  • Creation of an atlas of short brain fascicles.

  • Development of algorithms for the comparison of brain tracts, between subjects and between hemispheres.

Undergraduate Theses related to the project

Student Thesis Defense Date
Ignacio Osorio W. Electronic Civil Engineering Thesis: “Software for the Interactive Visualization and Extraction of Brain Fibers” December 31st, 2015.
Danilo Bonometti B. Electronic Civil Engineering Thesis: “Visualization of Brain Fibers” April 1st, 2015.
Daniel Seguel B. Biomedical Civil Engineering Thesis: “Automatic Algorithm for the Segmentation of Short Association Fibers of the Human Brain” March 17th, 2015.
Claudio Román G. Biomedical Civil Engineering Thesis: “Short Brain Fibers Clustering Calculated from Difussion Magnetic Resonance Imaging Images” January 16th, 2015.
Miguel Guevara O. Biomedical Civil Engineering Thesis: “Algorithm for the Automatic Segmentation of Short Brain Fibers of the Fronto-Parietal Region and the Insular Cortex” January 16th, 2015.
Pablo L. Silva P. Biomedical Civil Engineering Thesis: “Parcellation of the Brain Cortex Based on the Anatomical Connectivity” May 29th, 2014.
Eduardo Venegas A. Electronic Civil Engineering Thesis: “Development of a software for the interactive manipulation of brain fibers” July 18th, 2014.
Nicole A. Labra A. Biomedical Civil Engineering Thesis: “Optimization of Algorithm for the Classification of White Matter Fibers based on the Brain Fascicles Atlas” April 30th, 2013.
Edison Pardo R. Electronic Civil Engineering Thesis: “Study of the Variability of the Connections of Short Association of the Human Brain” April 4th, 2013.
Gabriel E. Varela M. Biomedical Civil Engineering Thesis: “Calculation of Diffusion Tensor Indices from the Westin Algorithm” April 4th, 2013.

Postgraduate Theses related to the project

Student Thesis Defense Date
Claudio Román G. Master of Engineering Sciences w/m in Electrical Engineering.
“Segmentation of brain short brain fibers based on hierarchical Clustering from HARDI database”
November 30th, 2016.
Miguel Guevara O. Master of Engineering Sciences w/m in Electrical Engineering.
“Parcellation of the brain cortex based on fiber atlas calculated from tractography”
January 30th, 2016.
Nicole Labra A. Master of Engineering Sciences w/m in Electrical Engineering, (co-director)
“Quick segmentation of white substance brain fibers”
January 28th, 2015.

Publications

2508, 2017

Biomedical Imaging Workshop at Faculty of Engineering, Universidad de Concepción

Biomedical Imaging Workshop at Faculty of Engineering, Universidad de Concepción On August 25th, 2017, the "Biomedical Imaging: Research and Clinical Applications" workshop took place at the Faculty of Engineering of our University. Guest lecturers: “Dr. Pablo Irarrázaval” (Electrical Civil Engineer, PhD), “Dr. Sergio Uribe” (Bachelor and Master in Engineering Sciences, PhD) and “Dr. Carlos Guevara” (Neurologist, PhD). FONDECYT 1161427

3105, 2017

Alumnus awarded with “Merit Abstract Travel Stipend” by the OHBM

Former Biomedical Civil Engineering student and Master in Electrical Engineering Miguel Guevara, was awarded the “Merit Abstract Travel Stipend” by the “Organization for the Human Brain Mapping” in the context of the 23rd version of its Annual Conference (OHBM 2017, https://www.humanbrainmapping.org/i4a/pages/index.cfm?pageID=3734), by his work titled “Cortex surface parcellation based on short association white matter bundles”. This acknowledgment is given to the best qualified papers, taking into account the hard work and quality science shown in them. The conference will be held June 25th to the 29th at Vancouver, Canada, where Miguel will present his work. FONDECYT 1161427

503, 2017

Interactive System for the Promotion of Language and Communication

Project Type: FONDEF ID16I10210 Two-Stage IDeA Program  Main Institution: Pontifical Catholic University of Chile. Associated Institution: University of Concepción. Position: Alternate Director. Award Year: 2017. Finishing Year: 2018. Director: Marcela Peña G. Alternate Director: Pamela Guevara A. Researchers: Esteban Pino Q., Enrica Pittaluga P. The Interactive Optimized Language Stimulation System – IOLSS (SIELO, in Spanish), is an educational technological toy developed as a mobile application for devices running Android OS. The choice of the technological platform is based on the wide access children have to smartphones or tablets [1][2], which makes it easier to present educational games to them. See poster presented at NER' 2019 conference. SIELO seeks to stimulate language, contingency and attention of children between ages 2 and 4, through cognitive tasks in the form of interactive games which are distributed by modules. This is because at two years old, children are already in a linguistic stage [3], which would be reinforced by the developed game. This reinforcement is performed through tasks, with which the child may expand their vocabulary, learning underused or infrequent words, for example "wheat". They can also learn the alphabet letters as well as their sound, such as "M" which sounds like "mmm". On the other hand, since a child at age three is already capable of naming objects [4], a module focused on stimulating speech; here the child is taught to vocalize both the words as well as the letters presented.  The developed application makes use of children's interest in technology, to promote in them the control of their attention, since to play and surpass the stages they must wait for answering turns, respecting the instructions given by the teacher. In each activity included in the game, the child is evaluated according to the type of answer given (correct, incorrect, or omitted), as well as the response time. All the data is saved in a database for posterior analysis. In SIELO, the child will be able to interact with the teacher, who aside from giving the game's instructions, also gives feedback based on the type of answer. Studies focused on the cognitive development of children point out that multimedia elements such as animations and sound effects are positive in maintaining the child's concentration, thus improving their learning process [5], which is why the teacher's videos have been specially designed for the application, as well as the objects in the videos chosen by specialists. SIELO consists of a main application with the game, and a complementary application for a tutor. The tutor's application is connected via Bluetooth to the main application in order to externally control the child's game, allowing for the evaluation of the child's vocalizations, pausing the game, start breaks, among others. References (all in Spanish except for [5]) [1] “Estudio VTR Internet Segura: Un 40% de los niños de 5 años tiene un celular propio con acceso a Internet” (2015) T13 Artículo Online. Mayo 2015. [Available Online: June 2017] [http://www.t13.cl/noticia/nacional/estudio-indica-que-40-de-los-ninos-de-5-anos-tiene-un-celular-propio-con-acceso-a-internet] [2] [...]

News

501, 2019

Prof. Pamela Guevara joins important international IEEE technical committee

Professor Pamela Guevara was accepted as an associate member of the "Bio Imaging and Signal Processing" (BISP) Technical Committee, of the IEEE's Signal Processing Society (SPS), [...]

2018-11-10T18:32:47-03:00

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