Development and optimization of tools for the study of human brain anatomical connectivity using high angular resolution diffusion MRI

Project Type: FONDECYT Initiation #11121644
Position: Principal Researcher
Award Year: 2012. Ending Year: 2015.

Descripción

This project sought to develop and optimize tools for the study and analysis of brain connectivity, using Difussion Magnetic Resonance Imaging (dMRI) data.

The studies are based on High Angular Resolution Difussion Imaging (HARDI) images.

These present very high quality, due to the advancement of acquisition technologies, as well as the acquisition itself (long duration, dedicated to research) and the performed post-processing, which seek to provide a solid base for the study of the healthy adult human brain.

The main results of this project contemplate:

  • The analysis of the reproducibility of short association fascicles of the brain, using data clustering tools and cortical parcellations.

  • The optimization of an algorithm for the segmentation of brain fibers, achieving times that allow an interactive segmentation (Principal Researcher: Professor Miguel Figueroa T.).

  • The development of a tool for the optimized visualization and manipulation of brain tracts.

Other interesting results are:

  • Development of a tool for the optimized visualization of tracts for Android devices (iFiber).

  • Creation of an atlas of short brain fascicles.

  • Development of algorithms for the comparison of brain tracts, between subjects and between hemispheres.

Undergraduate Theses related to the project

Student Thesis Defense Date
Ignacio Osorio W. Electronic Civil Engineering Thesis: “Software for the Interactive Visualization and Extraction of Brain Fibers” December 31st, 2015.
Danilo Bonometti B. Electronic Civil Engineering Thesis: “Visualization of Brain Fibers” April 1st, 2015.
Daniel Seguel B. Biomedical Civil Engineering Thesis: “Automatic Algorithm for the Segmentation of Short Association Fibers of the Human Brain” March 17th, 2015.
Claudio Román G. Biomedical Civil Engineering Thesis: “Short Brain Fibers Clustering Calculated from Difussion Magnetic Resonance Imaging Images” January 16th, 2015.
Miguel Guevara O. Biomedical Civil Engineering Thesis: “Algorithm for the Automatic Segmentation of Short Brain Fibers of the Fronto-Parietal Region and the Insular Cortex” January 16th, 2015.
Pablo L. Silva P. Biomedical Civil Engineering Thesis: “Parcellation of the Brain Cortex Based on the Anatomical Connectivity” May 29th, 2014.
Eduardo Venegas A. Electronic Civil Engineering Thesis: “Development of a software for the interactive manipulation of brain fibers” July 18th, 2014.
Nicole A. Labra A. Biomedical Civil Engineering Thesis: “Optimization of Algorithm for the Classification of White Matter Fibers based on the Brain Fascicles Atlas” April 30th, 2013.
Edison Pardo R. Electronic Civil Engineering Thesis: “Study of the Variability of the Connections of Short Association of the Human Brain” April 4th, 2013.
Gabriel E. Varela M. Biomedical Civil Engineering Thesis: “Calculation of Diffusion Tensor Indices from the Westin Algorithm” April 4th, 2013.

Postgraduate Theses related to the project

Student Thesis Defense Date
Claudio Román G. Master of Engineering Sciences w/m in Electrical Engineering.
“Segmentation of brain short brain fibers based on hierarchical Clustering from HARDI database”		 November 30th, 2016.
Miguel Guevara O. Master of Engineering Sciences w/m in Electrical Engineering.
“Parcellation of the brain cortex based on fiber atlas calculated from tractography”		 January 30th, 2016.
Nicole Labra A. Master of Engineering Sciences w/m in Electrical Engineering, (co-director)
“Quick segmentation of white substance brain fibers”		 January 28th, 2015.

Publications

2311, 2017

Mobile Application for Seniors in the Treatment of Arterial Hypertension

C. Vásquez, P. Guevara, R. Pinto, R. Iturra, C. Alvial, L. Sufán, A. Hernández, F. Venegas, R. Aguilera, M.P. Casanova, T. Moreno, M. Victoriano, I. Chamblás, P. Cid, H. Müller, M.J. Sepúlveda. Mobile Application for Seniors in the Treatment of Arterial Hypertension. I Seminar of Health Informatics, Valparaíso, Chile, 2017.

2311, 2017

Outstanding participation of Biomedical Engineers at Health Informatics Seminar

A delegation of 10 students and alumni of Biomedical Civil Engineering attended the I Health Informatics Seminar, organized by the University of Valparaíso, on November 23rd and 24th. (http://www.sis2017.cl/). Constanza Vázquez, Biomedical Civil Engineer of UdeC obtained the 1st place in the Paper Contest, with the paper "Mobile Application for Seniors on the Treatment of Arterial Hypertension", which was developed in the context of the Project "Transmedial psychoeducational program to improve farmacological adherence of antihypertensive treatment in seniors: Pilot project". (FONDEF ID16AM0007 http://www.afamudec.cl/). The director of said project is Jacqueline Sepúlveda, from the Faculty of Biological Sciences, and in which Pamela Guevara, Director of Biomedical Engineering Udec, participates as researcher along with a multidisciplinary group, composed of both students and professor from different faculties.                     Constanza Vásquez obtained the 1st place in the Paper Contest   Original article FI UdeC (spanish): http://www.ing.udec.cl/noticias/destacada-participacion-de-ing-biomedicos-en-seminario-de-informatica-en-salud/

3010, 2017

Researcher Jean-François Mangin dictates inaugural session at X Biomedical Civil Engineering Congress – UdeC

More than a hundred students from different national universities and the host career, reunited at the X Anual Biomedical Engineering Congress (CAIB), which took place at the end of October, 2017, at Universidad de Concepción. The opening session included the participation of the brain study center "Neurospin" researcher (laboratory associated to the French Atomic Energy Comission (CEA)), Dr. Jean-François Mangin, who had at his charge the first conference of the encounter, "Deciphering the patterns of cortical folding to evaluate the risk of psychiatric diseases". See the full news at Diario Concepción and Facultad de Ingeniería-UdeC.

1510, 2017

Superficial white matter integrity in autism spectrum disorders.

M.A. D’Albis, P. Guevara, M. Guevara, J. Mangin, C. Poupon, D. Duclap, C. Laidi, J. Boigontier, R. Delorme, F. Bolognani, C. Czech, J. Moreau, C. Bouquet, E. Toledano, M. Bouvard, M. Caralp, S. Gueguen, I. Scheid, A. Gaman, M. Leboyer, J. Houenou. Superficial white matter integrity in autism spectrum disorders. European College of Neuropsychopharmacology Congress (ENCP), Paris, France, 2017. DOI: https://doi.org/10.1016/S0924-977X(17)31298-1

2909, 2017

Course: Technology and biomedical applications of Magnetic Resonance, Santiago, Chile

   September 29th of 2017 the “Technology and biomedical applications of Magnetic Resonance” course took place at the Innovation Center - San Joaquín UC Campus, at Santiago, Chile.   Course lecturers: “Dr. Pablo Irarrázaval” (Electrica Civil Engineer, PhD). “Dr. Attilio Rigotti” (Internal Medicine Specialist, PhD). “Dr. Cristián Tejos” (Industry Civil Engineer w/m in Electricity, PhD). “Dr. Sergio Uribe” (Bachelor and Masters in Engineering Sciences, PhD). “Dr. Marcelo Andía” (Industry Civil Engineer w/m in Mechanics, PhD).   The course was attended by undergraduate students Daniela Pinto and Nicolás Cárdenas, the masters student Claudio Huaiqueo, and the PhD student Claudio Román.

2508, 2017

Biomedical Engineering in Special Edition about Health Informatics in El Mercurio newspaper

We highlight a report about Biomedical Civil Engineering of University of Concepción in El Mercurio newspaper, in its special edition about Health Informatics, from August 24th, 2017. Biomedical Engineering's Director, professor Pamela Guevara, highlights the most important characteristics of the major, as well as the graduate profile and the occupational field. The SmartFES device developed by professor Pablo Aqueveque and Biomedical Engineer Francisco Saavedra is highlighted as well. See the full publication at Diario El Mercurio.  

News

2018-11-10T18:32:47-03:00

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