Development and optimization of tools for the study of human brain anatomical connectivity using high angular resolution diffusion MRI

Project Type: FONDECYT Initiation #11121644
Position: Principal Researcher
Award Year: 2012. Ending Year: 2015.

Descripción

This project sought to develop and optimize tools for the study and analysis of brain connectivity, using Difussion Magnetic Resonance Imaging (dMRI) data.

The studies are based on High Angular Resolution Difussion Imaging (HARDI) images.

These present very high quality, due to the advancement of acquisition technologies, as well as the acquisition itself (long duration, dedicated to research) and the performed post-processing, which seek to provide a solid base for the study of the healthy adult human brain.

The main results of this project contemplate:

  • The analysis of the reproducibility of short association fascicles of the brain, using data clustering tools and cortical parcellations.

  • The optimization of an algorithm for the segmentation of brain fibers, achieving times that allow an interactive segmentation (Principal Researcher: Professor Miguel Figueroa T.).

  • The development of a tool for the optimized visualization and manipulation of brain tracts.

Other interesting results are:

  • Development of a tool for the optimized visualization of tracts for Android devices (iFiber).

  • Creation of an atlas of short brain fascicles.

  • Development of algorithms for the comparison of brain tracts, between subjects and between hemispheres.

Undergraduate Theses related to the project

Student Thesis Defense Date
Ignacio Osorio W. Electronic Civil Engineering Thesis: “Software for the Interactive Visualization and Extraction of Brain Fibers” December 31st, 2015.
Danilo Bonometti B. Electronic Civil Engineering Thesis: “Visualization of Brain Fibers” April 1st, 2015.
Daniel Seguel B. Biomedical Civil Engineering Thesis: “Automatic Algorithm for the Segmentation of Short Association Fibers of the Human Brain” March 17th, 2015.
Claudio Román G. Biomedical Civil Engineering Thesis: “Short Brain Fibers Clustering Calculated from Difussion Magnetic Resonance Imaging Images” January 16th, 2015.
Miguel Guevara O. Biomedical Civil Engineering Thesis: “Algorithm for the Automatic Segmentation of Short Brain Fibers of the Fronto-Parietal Region and the Insular Cortex” January 16th, 2015.
Pablo L. Silva P. Biomedical Civil Engineering Thesis: “Parcellation of the Brain Cortex Based on the Anatomical Connectivity” May 29th, 2014.
Eduardo Venegas A. Electronic Civil Engineering Thesis: “Development of a software for the interactive manipulation of brain fibers” July 18th, 2014.
Nicole A. Labra A. Biomedical Civil Engineering Thesis: “Optimization of Algorithm for the Classification of White Matter Fibers based on the Brain Fascicles Atlas” April 30th, 2013.
Edison Pardo R. Electronic Civil Engineering Thesis: “Study of the Variability of the Connections of Short Association of the Human Brain” April 4th, 2013.
Gabriel E. Varela M. Biomedical Civil Engineering Thesis: “Calculation of Diffusion Tensor Indices from the Westin Algorithm” April 4th, 2013.

Postgraduate Theses related to the project

Student Thesis Defense Date
Claudio Román G. Master of Engineering Sciences w/m in Electrical Engineering.
“Segmentation of brain short brain fibers based on hierarchical Clustering from HARDI database”
November 30th, 2016.
Miguel Guevara O. Master of Engineering Sciences w/m in Electrical Engineering.
“Parcellation of the brain cortex based on fiber atlas calculated from tractography”
January 30th, 2016.
Nicole Labra A. Master of Engineering Sciences w/m in Electrical Engineering, (co-director)
“Quick segmentation of white substance brain fibers”
January 28th, 2015.

Publications

3007, 2018

Innovative App for the improvement of farmacological adherence in seniors is recognized

The Diario Concepción newspaper highlighted the development of a Innovative App to improve the farmacological adherence in hypertensive seniors, in the context of FONDEF ID16AM0007 PROJECT "Transmedial psychoeducational program to improve farmacological adherence of antihypertensive treatment in seniors: Pilot project", led by Dr. Jacqueline Sepúlveda. The development of the app in its technical aspects was led by professor Pamela Guevara, and implemented by Biomedical Civil Engineer of Udec, Constanza Vásquez. It is worth noting that the Project's team is multidisciplinary, with researchers and professionals from different areas: - Jacqueline Sepúlveda (director) and Rayen Pinto, Roberto Iturra, Faculty of Biological Sciences - Hans Müller (alternate director), Faculty of Medicine - Isis Chamblás, Tabita Moreno y Fernando Venegas, Faculty of Social Sciences - Montserrat Victoriano, Faculty of Pharmacy - María Paz Casanova, Faculty of Physics Sciences and Mathematics - Pamela Guevara, Faculty of Engineering - Rosa Aguilera, Faculty of Economic and Administrative Sciences - Patricia Cid, Faculty of Nursing - Camila Alvial, Industrial Designer, AIEP - Adolfo Hernández, Journalist, UdeC Plus a large number of collaborating students from different faculties. Among them we highlight the Biomedical Engineering student, Christopher Vergara, who helped in the digital alfabetization of the seniors via home visits. Full interview in Diario Concepción.  

1505, 2018

Professor Pamela Guevara in “Women in Science and Technology” report

Professor Pamela Guevara appeared in a reportage from El Sur newspaper titled "Women in Science: family determines the freedom to dare", along with two other young professionals of the area. In this, the academic and current Biomedical Civil Engineering Director talks about her time as a student at Universidad de Concepción, the gender gap in her major, and the importance of her parents' support and motivation for her to study whatever she wanted, no matter the prejudice associated to a woman in science. When I was a kid my interest was always towards science. And my parents always encouraged me to study whatever I wanted, and they really liked that I choose engineering, not only because my dad was one, but also because they know I liked everything about engineering. The article aims to highlight the importance of family support in women and young female students that wish to develop in science and technology, with the goal of overcoming the prejudices associated to them in STEM (Sciente, Technology, Engineering, Mathematics) vocations. Regarding that, professor Pamela says: Since very little, girls are encouraged and congratulated by looking pretty, smile or having a nice gesture; and the boys when they achieve concrete objective, like solving a puzzle... ...I believe that the fear to participate or encourage STEM vocations in girls and young females is because there is ignorance that, in fact, there are no difference between the development of boys and girls, as people usually think. Source: Diario El Sur. Complete reportage in http://www.elsur.cl/impresa/2018/04/24/full/cuerpo-principal/16/.  

1405, 2018

Professor Pamela Guevara distinguished in 100 Female UdeC Engineers Campaign

Professor Pamela Guevara, Biomedical Civil Engineering Director, Electronic Civil Engineer from UdeC, PhD in Physics of Paris-Sud University (France) is one of the few people that work on difussion Magnetic Resonance in Latin America. It counts with international level researchs and publications in the most prestigious journals of the area. She was highlighted in the "100 Female UdeC Engineers", Faculty of Engineering, University of Concepción. Full interview at: http://www.ing.udec.cl/…/nosotras-creemos-en-la-igualdad-o…/.

1603, 2018

A novel method to detect fractional anisotropy differences in short association fibers discriminated by their functional connectivity between Multiple Sclerosis patients and healthy subjects.

C. Montalba, M. Zurita, T. Labbé, P. Guevara , C. Carcamo , J. P. Cruz , C. Sing-Long, M. Andia, S. Uribe. A novel method to detect fractional anisotropy differences in short association fibers discriminated by their functional connectivity between Multiple Sclerosis patients and healthy subjects. In International Society of Magnetic Resonance in Medicine conference, ISMRM 2018, Paris, France, 2018.

News

1106, 2019

Ignacio Osorio Wallace presented at OHBM 2019 (the Organization for Human Brain Mapping annual meeting)

On June 11th 2019, Electronic Engineer Ignacio Osorio Wallace participated in OHBM (Organization for Human Brain Mapping) 2019, where he presented a paper entitled "FiberVis: [...]

2018-11-10T18:32:47-03:00

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